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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $65 | In Stock | |
1 g | $98 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. |
In vivo | In AR4-2J cells, Menadione (1-20 mM) inhibits cell proliferation in a dose- and time-dependent manner. In the RALA255-10G rat liver cell line, Menadione activates extracellular signal-regulated kinase and c-Jun N-terminal kinase. Furthermore, Menadione suppresses multidrug-resistant leukemia cell lines (IC50=13.5 mM) and primary leukemia cell lines (IC50=18 mM). At 100 mM, Menadione induces DNA fragmentation, leading to rapid cell death. Additionally, in normal pancreatic acinar cells, Menadione inhibits mitochondrial Ca(2+) uptake. |
Alias | Vitamin K3 |
Molecular Weight | 172.18 |
Formula | C11H8O2 |
Cas No. | 58-27-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 32 mg/mL (185.9 mM) DMSO: 55 mg/mL (319.43 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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