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Menadione

🥰Excellent
Catalog No. T0449Cas No. 58-27-5
Alias Vitamin K3

Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Menadione

Menadione

🥰Excellent
Purity: 99.08%
Catalog No. T0449Alias Vitamin K3Cas No. 58-27-5
Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Pack SizePriceAvailabilityQuantity
500 mg61 €In Stock
1 g93 €In Stock
1 mL x 10 mM (in DMSO)47 €In Stock
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Purity:99.08%
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Product Introduction

Bioactivity
Description
Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
In vivo
In AR4-2J cells, Menadione (1-20 mM) inhibits cell proliferation in a dose- and time-dependent manner. In the RALA255-10G rat liver cell line, Menadione activates extracellular signal-regulated kinase and c-Jun N-terminal kinase. Furthermore, Menadione suppresses multidrug-resistant leukemia cell lines (IC50=13.5 mM) and primary leukemia cell lines (IC50=18 mM). At 100 mM, Menadione induces DNA fragmentation, leading to rapid cell death. Additionally, in normal pancreatic acinar cells, Menadione inhibits mitochondrial Ca(2+) uptake.
AliasVitamin K3
Chemical Properties
Molecular Weight172.18
FormulaC11H8O2
Cas No.58-27-5
SmilesO=C1C=2C(C(=O)C=C1C)=CC=CC2
Relative Density.1.225 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 32 mg/mL (185.9 mM)
DMSO: 55 mg/mL (319.43 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM5.8079 mL29.0394 mL58.0788 mL290.3938 mL
5 mM1.1616 mL5.8079 mL11.6158 mL58.0788 mL
10 mM0.5808 mL2.9039 mL5.8079 mL29.0394 mL
20 mM0.2904 mL1.4520 mL2.9039 mL14.5197 mL
50 mM0.1162 mL0.5808 mL1.1616 mL5.8079 mL
100 mM0.0581 mL0.2904 mL0.5808 mL2.9039 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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