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Parmodulin 2
🥰Excellent
Catalog No. T1893Cas No. 423735-93-7
Alias ML 161
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.
Parmodulin 2
🥰Excellent
Purity: 99.95%
Catalog No. T1893Alias ML 161Cas No. 423735-93-7
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $61 | In Stock | |
| 10 mg | $85 | In Stock | |
| 25 mg | $158 | In Stock | |
| 50 mg | $255 | In Stock | |
| 100 mg | $396 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $59 | In Stock |
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Purity:99.95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation. |
| Targets&IC50 | PAR1:0.26 μM |
| In vivo | Through P-selectin expression assays, ML-161 has been found to inhibit thrombin-induced platelet activation in a dose-dependent manner. ML-161 selectively inhibits platelet aggregation induced by SFLLRN and thrombin through PAR1 (proteinase-activated receptor 1), without affecting platelet aggregation triggered by AYPGKF, thromboxane, or ADP (adenosine diphosphate). |
| Alias | ML 161 |
| Molecular Weight | 361.23 |
| Formula | C17H17BrN2O2 |
| Cas No. | 423735-93-7 |
| Smiles | CCCC(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1 |
| Relative Density. | 1.441 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 36.1 mg/mL (100 mM) Ethanol: 36.1 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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