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PAR-2-IN-1
🥰Excellent
Catalog No. T8917Cas No. 1690176-75-0
Alias IUN76750
PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
PAR-2-IN-1
🥰Excellent
Purity: 99.75%
Catalog No. T8917Alias IUN76750Cas No. 1690176-75-0
PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $83 | In Stock | |
| 25 mg | $173 | In Stock | |
| 50 mg | $269 | In Stock | |
| 100 mg | $395 | In Stock | |
| 200 mg | $557 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $51 | In Stock |
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Trypsin
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Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin could induce the cell membrane fusion of PDCoV-infected cells through the interaction between the S glycoprotein of PDCoV and pAPN, activate PAR2 and PAR4, and promote cell proliferation and differentiation. Trypsin can be used to promote wound healing and study neurogenic inflammation.
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Atopaxar
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Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.
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Vorapaxar
Cited
SCH 530348, MK-5348
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Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
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CitedVorapaxar sulfate
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Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.
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AY 77
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T411901835734-92-3In house
AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
- $412
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ML-354
VU0099704, VU 0099704, ML354
T2190189159-60-4
ML-354 (VU0099704) is a selective and potent PAR4 antagonist for the study of cardiovascular disease.
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PAR-2 Activating Peptide acetate
SLIGRL-NH2 acetate, Protease-Activated Receptor-2 Activating Peptide acetate, PAR-2 Activating Peptide acetate(171436-38-7 free base)
TP1046L
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).
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FSLLRY-NH2 TFA(245329-02-6 free base)
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FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
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LRGILS-NH2 acetate
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LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.
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VKGILS-NH2 Acetate
VKGILS-NH2 Acetate (942413-05-0 Free base)
T21699L
VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.
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Protease-Activated Receptor-1, PAR-1 Agonist acetate
T38836L
Protease-Activated Receptor-1, PAR-1 Agonist acetate is a selective proteinase-activated receptor1Â (PAR-1)Â agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist acetate corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2].
- $133
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AC-55541
AOB2796
T2370916170-19-9
AC-55541 (AOB2796) is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM.
- $29
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Purity:99.75%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects. |
| Alias | IUN76750 |
| Molecular Weight | 267.71 |
| Formula | C12H14ClN3O2 |
| Cas No. | 1690176-75-0 |
| Smiles | COC(=O)c1cn2nc(Cl)cc(c2n1)C(C)(C)C |
| Relative Density. | 1.31 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 83.33 mg/mL (311.27 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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