Shopping Cart
- Remove All
- Your shopping cart is currently empty
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $38 | In Stock | |
5 mg | $61 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $243 | In Stock | |
50 mg | $428 | In Stock | |
100 mg | $635 | In Stock | |
1 mL x 10 mM (in DMSO) | $78 | In Stock |
Description | AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM). |
Targets&IC50 | PAR2:23 nM(kd) |
In vitro | AZ3451 is selective for PAR2 over PAR4 and PAR1 (IC50s = <2.5, 380, and >50,000 nM, respectively, in a β-arrestin-2 recruitment assay). AZ3541 completely inhibits SLIGRL-induced phosphorylation of ERK in 1321N1 astrocytoma cells when used at a concentration of 10 μM. |
Molecular Weight | 571.46 |
Formula | C30H27BrN4O3 |
Cas No. | 2100284-59-9 |
Smiles | C[C@@H](C1CCCCC1)n1c(nc2cc(ccc12)C(=O)Nc1ccc(cc1)C#N)-c1cc2OCOc2cc1Br |
Relative Density. | 1.49 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: Insoluble DMSO: 80 mg/mL (140 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.