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DS-1040 Tosylate
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Catalog No. T11100Cas No. 1335138-89-0
Alias DS1040 Tosylate
DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFIa) inhibitor, also a fibrinolysis enhancer, inhibiting TAFIa and carboxypeptidase N, reducing fibrin clots in the lungs, useful in thromboembolic disease research.
DS-1040 Tosylate
😃Good
Catalog No. T11100Alias DS1040 TosylateCas No. 1335138-89-0
DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFIa) inhibitor, also a fibrinolysis enhancer, inhibiting TAFIa and carboxypeptidase N, reducing fibrin clots in the lungs, useful in thromboembolic disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $119 | In Stock | |
| 25 mg | $614 | 8-10 weeks | |
| 50 mg | $798 | 8-10 weeks | |
| 100 mg | $1,360 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DS-1040 Tosylate is a thrombin-activated fibrinolysis inhibitor (TAFIa) inhibitor, also a fibrinolysis enhancer, inhibiting TAFIa and carboxypeptidase N, reducing fibrin clots in the lungs, useful in thromboembolic disease research. |
| Targets&IC50 | TAFIa (rat):8.01 nM, TAFIa (human):5.92 nM |
| In vitro | DS-1040 Tosylate inhibited human carboxypeptidase N (CPN) in vitro with an IC50 of 3.02 mM.[1] |
| In vivo | Methods: DS-1040 Tosylate (0.016, 0.031, 0.063, 0.13, 0.25, 0.50 mg/kg, intravenous injection) was administered to mice with microthrombosis model to investigate the pharmacokinetic changes in vivo. Results: DS-1040 Tosylate increased plasma D-dimer levels in a dose-dependent manner. ED50 and EDmax were 122 and 221nM, respectively. Methods: DS-1040 Tosylate (0.25, 0.5, 1, 2, 4, 8, 16 mg/kg; oral administration) was administered to mice with microthrombosis model to investigate the pharmacokinetic changes in vivo. Results: DS-1040 Tosylate increased plasma D-dimer levels, with EC50 and ECmax values of 114 and 231 nmol/L, respectively.[1] |
| Alias | DS1040 Tosylate |
| Molecular Weight | 465.61 |
| Formula | C23H35N3O5S |
| Cas No. | 1335138-89-0 |
| Smiles | S(=O)(=O)(O)C1=CC=C(C)C=C1.C([C@H](CCCN)C(O)=O)C1=CN(C=N1)[C@H]2CC[C@H](C)CC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | store at 4°C | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 40 mg/mL (85.91 mM), Sonication is recommended. DMSO: 80 mg/mL (171.82 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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