Shopping Cart

Remove All
Your shopping cart is currently empty

DS-1040 Tosylate

Name: DS-1040 Tosylate
Brand: TargetMol
SKU: T11100
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T11100Cas No. 1335138-89-0

DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases[1].

DS-1040 Tosylate

😃Good

Catalog No. T11100Cas No. 1335138-89-0

Pack Size	Price	Availability
2 mg	$119	5 days
25 mg	$614	8-10 weeks
50 mg	$798	8-10 weeks
100 mg	$1,360	8-10 weeks

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM
Targets&IC50	TAFIa (human):5.92 nM , TAFIa (rat):8.01 nM
In vitro	Ds-1040 Tosylate inhibited human carboxypeptidase N (CPN) in vitro with an IC50 of 3.02 mM.
In vivo	DS-1040 Tosylate (0.0005-0.5 mg/kg; IV) significantly reduces the microthrombi index at doses of 0.005 mg/kg and greater. DS-1040 (0.016-0.50 mg/kg; i.v.) increases plasma D-dimer levels dose-dependently in a microthrombosis model, with ED50 and EDmax of 122 and 221 nmol/L, respectively. Orally administered DS-1040 (0.25-16 mg/kg) also increases plasma D-dimer levels, with EC50 and ECmax values of 114 and 231 nmol/L, respectively.

Chemical Properties

Molecular Weight	465.61
Formula	C₂₃H₃₅N₃O₅S
Cas No.	1335138-89-0
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 100 mg/mL (214.77 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1477 mL	10.7386 mL	21.4772 mL	107.3860 mL
5 mM	0.4295 mL	2.1477 mL	4.2954 mL	21.4772 mL
10 mM	0.2148 mL	1.0739 mL	2.1477 mL	10.7386 mL
20 mM	0.1074 mL	0.5369 mL	1.0739 mL	5.3693 mL
50 mM	0.0430 mL	0.2148 mL	0.4295 mL	2.1477 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0739 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DS1040 TosylateDS-1040 TosylateDS 1040 Tosylate