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Product Introduction

Bioactivity

Description	1. Buddlejasaponin IVb (Saikosaponin 1b)(200 uM) can shorten thrombin time (TT) by 20.6 %, suggests that it has hemostasis efficacy.
Alias	Saikosaponin 1b

Chemical Properties

Molecular Weight	943.12
Formula	C₄₈H₇₈O₁₈
Cas No.	152580-79-5
Smiles	[H][C@@]1(O[C@H]2[C@@H](O)[C@@H](C)O[C@@]([H])(O[C@H]3CC[C@@]4(C)[C@@]([H])(CC[C@]5(C)[C@]4([H])C=CC4=C6CC(C)(C)CC[C@]6(CO)[C@@H](O)C[C@@]54C)[C@]3(C)CO)[C@@H]2O[C@]2([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 91 mg/mL (96.5 mM)

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0603 mL	5.3016 mL	10.6031 mL	53.0155 mL
5 mM	0.2121 mL	1.0603 mL	2.1206 mL	10.6031 mL
10 mM	0.1060 mL	0.5302 mL	1.0603 mL	5.3016 mL
20 mM	0.0530 mL	0.2651 mL	0.5302 mL	2.6508 mL
50 mM	0.0212 mL	0.1060 mL	0.2121 mL	1.0603 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitBuddlejasaponin IVb