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12(S)-HETrE
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Catalog No. T36773Cas No. 72710-10-2
12(S)-HETrE is an endogenous metabolite produced by oxidation of ω-6 PUFA dihomo-γ-linolenic acid (DGLA) by 12-lipoxygenase (12-LOX) in platelets, which acts on Gαs-coupled G-protein-coupled receptors, has antithrombotic properties, and has potential therapeutic use in cardiovascular disease. 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.
12(S)-HETrE
😃Good
Catalog No. T36773Cas No. 72710-10-2
12(S)-HETrE is an endogenous metabolite produced by oxidation of ω-6 PUFA dihomo-γ-linolenic acid (DGLA) by 12-lipoxygenase (12-LOX) in platelets, which acts on Gαs-coupled G-protein-coupled receptors, has antithrombotic properties, and has potential therapeutic use in cardiovascular disease. 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg | $230 | 35 days | |
| 50 μg | $438 | 35 days | |
| 100 μg | $828 | 35 days |
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Concentration:0.1 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | 12(S)-HETrE is an endogenous metabolite produced by oxidation of ω-6 PUFA dihomo-γ-linolenic acid (DGLA) by 12-lipoxygenase (12-LOX) in platelets, which acts on Gαs-coupled G-protein-coupled receptors, has antithrombotic properties, and has potential therapeutic use in cardiovascular disease. 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activation, Rap1 activation, and thrombin-induced clot retraction in vitro. |
| In vitro | 12(S)-HETrE (20, 40 μM) treated platelets, and at a concentration of 40 μM, platelets are sensitive to them, which can have an inhibitory effect on platelets. [1] |
| Molecular Weight | 322.48 |
| Formula | C20H34O3 |
| Cas No. | 72710-10-2 |
| Smiles | C(\[C@H](C/C=C\CCCCC)O)=C/C=C\CCCCCCC(O)=O |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | 0.1 M Na2CO3: 4.00 mg/mL (12.40 mM), Sonication is recommended. PBS (pH 7.2): < 1 mg/ml (slightly soluble or insoluble), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
0.1 M Na2CO3
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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