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RG7800 hydrochloride (1449598-06-4 free base)

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RG7800 hydrochloride (1449598-06-4 free base)

Catalog No. T12718

RG7800 hydrochloride is an orally active modulator of SMN2 splicing.

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Pack Size	Price	Availability
5 mg	$108	Backorder
10 mg	$171	Backorder
50 mg	$584	Backorder
100 mg	$873	Backorder
200 mg	Inquiry	Backorder
500 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	RG7800 hydrochloride is an orally active modulator of SMN2 splicing.
Targets&IC50	SMN2 splicing: 87 nM , SMN protein:, EC1.5x: 23 nM
In vitro	RG7800 hydrochloride is an orally active modulator of SMN2 splicing(EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein).RG7800 hydrochloride is the first small molecule SMN2 splicing modifier to enter human clinical trials.
In vivo	RG7800 dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice. RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability.
Alias	RO6885247 hydrochloride, RG7800 hydrochloride

Chemical Properties

Formula	C24H28N6O.xHCl
Cas No.

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O: 113.5 mg/mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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Keywords

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