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RG7800 hydrochloride (1449598-06-4 free base)
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Catalog No. T12718
Alias RO6885247 hydrochloride, RG7800 hydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing.
RG7800 hydrochloride (1449598-06-4 free base)
😃Good
Catalog No. T12718Alias RO6885247 hydrochloride, RG7800 hydrochloride
RG7800 hydrochloride is an orally active modulator of SMN2 splicing.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $108 | Backorder | |
| 10 mg | $171 | Backorder | |
| 50 mg | $584 | Backorder | |
| 100 mg | $873 | Backorder | |
| 200 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RG7800 hydrochloride is an orally active modulator of SMN2 splicing. |
| Targets&IC50 | EC1.5x: 23 nM , SMN protein:, SMN2 splicing: 87 nM |
| In vitro | RG7800 hydrochloride is an orally active modulator of SMN2 splicing(EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein).RG7800 hydrochloride is the first small molecule SMN2 splicing modifier to enter human clinical trials. |
| In vivo | RG7800 dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice. RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. |
| Alias | RO6885247 hydrochloride, RG7800 hydrochloride |
| Formula | C24H28N6O.xHCl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O: 113.5 mg/mL |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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