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RG7800 tetrahydrochloride
Catalog No. T78046
Alias RO6885247 tetrahydrochloride
RG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50 values of 23 nM for splicing and 87 nM for SMN protein production, holding promise as a therapeutic agent for [spinal muscular atrophy].
RG7800 tetrahydrochloride
RG7800 tetrahydrochloride
Catalog No. T78046Alias RO6885247 tetrahydrochloride
RG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50 values of 23 nM for splicing and 87 nM for SMN protein production, holding promise as a therapeutic agent for [spinal muscular atrophy].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $42 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50 values of 23 nM for splicing and 87 nM for SMN protein production, holding promise as a therapeutic agent for [spinal muscular atrophy]. |
| In vitro | RG7800 hydrochloride is an orally active SMN2 splicing modulator with EC50s of 23 nM for SMN2 splicing and 87 nM for SMN protein production. It is the first small molecule SMN2 splicing modifier to advance into human clinical trials [1]. |
| In vivo | RG7800 exhibits a favorable metabolism and pharmacokinetic (DMPK) profile in both rats and cynomolgus monkeys, paired with good oral bioavailability. Administered at doses of 1, 3, and 10 mg/kg orally, RG7800 dose-dependently increases SMN protein levels in both the central nervous system and peripheral tissues of Δ7 mice [1]. |
| Alias | RO6885247 tetrahydrochloride |
| Molecular Weight | 562.36 |
| Formula | C24H32Cl4N6O |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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