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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $397 | In Stock | |
5 mg | $834 | In Stock | |
10 mg | $1,130 | In Stock | |
25 mg | $1,690 | In Stock | |
50 mg | $2,290 | In Stock | |
100 mg | $2,970 | In Stock | |
1 mL x 10 mM (in DMSO) | $954 | In Stock |
Description | RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter. |
In vitro | RJW100 (compound 24-exo) treatment significantly increases small/short heterodimer partner (SHP) transcripts in a dose-dependent manner starting at 5 µM. It almost completely displaces bound PIP2 phospholipid from SF-1 at 1 µM. Using hLRH-1 LBD alone without any phospholipids, a clear dose-dependent shift in hLRH-1 LBD native PAGE migration is observed with RJW100 (compound 24-exo; 0-100 µM) binding[1]. RJW100 strongly activates the miR-200c promoter and effectively downregulates ZEB1 and ZEB2 proteins[2]. |
Molecular Weight | 386.57 |
Formula | C28H34O |
Cas No. | 1276664-20-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (142.27 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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