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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,670 | 6-8 weeks | |
50 mg | $2,180 | 6-8 weeks | |
100 mg | $2,800 | 6-8 weeks |
Description | Ro 15-2041, a selective inhibitor of platelet phosphodiesterase, exhibits notable antithrombotic properties. |
In vitro | Ro 15-2041 inhibits platelet aggregation induced by common agonists in platelet-rich plasma from various species, including humans, with an IC50 of 1-3 μM. It enhances prostacyclin-induced platelet inhibition, increases (c) AMP levels, and inhibits collagen-induced release of serotonin and beta-thromboglobulin. It also reduces and normalizes cytosolic free Ca2+ levels in thrombin-stimulated human platelets. Ro 15-2041 is a potent (IC50 = 70 nM) and selective inhibitor of platelet cAMP-phosphodiesterase activity. |
Molecular Weight | 294.15 |
Formula | C12H12BrN3O |
Cas No. | 77448-87-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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