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RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $173 | In Stock | |
5 mg | $433 | In Stock | |
10 mg | $695 | In Stock | |
25 mg | $1,060 | In Stock | |
50 mg | $1,430 | In Stock |
Description | RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders. |
Targets&IC50 | HCN1:0.046 µM, HCN3:4.6 µM, HCN2:14.3 µM, HCN4:13.9 µM |
In vitro | RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6 and 13.9 µM for HCN1, HCN2, HCN3 and HCN4, respectively. [1] |
In vivo | RO-275 (3, 10 and 30 mg/kg, intraperitoneally injected) can save the reduction of working memory in rats. [1] |
Alias | RO275 |
Molecular Weight | 351.79 |
Formula | C18H14ClN5O |
Cas No. | 2648837-04-9 |
Smiles | O=C(N)C1=NC(C#CC=2C=CN=C(Cl)C2C)=C(N1C=3C=NC=CC3)C |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4 mg/mL (11.37 mM), Sonication and heating are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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