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RO-275

🥰Excellent
Catalog No. T87339Cas No. 2648837-04-9
Alias RO275

RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders.

RO-275

RO-275

🥰Excellent
Purity: 98.12%
Catalog No. T87339Alias RO275Cas No. 2648837-04-9
RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders.
Pack SizePriceAvailabilityQuantity
1 mg$173 In Stock
5 mg$433 In Stock
10 mg$695 In Stock
25 mg$1,060 In Stock
50 mg$1,430 In Stock
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Purity:98.12%
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Product Introduction

Bioactivity
Description
RO-275 is a selective HCN1 inhibitor with oral activity, also inhibiting HCN2, HCN3, and HCN4. It improves working memory and is used in research on cognitive disorders.
Targets&IC50
HCN1:0.046 µM, HCN3:4.6 µM, HCN2:14.3 µM, HCN4:13.9 µM
In vitro
RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6 and 13.9 µM for HCN1, HCN2, HCN3 and HCN4, respectively. [1]
In vivo
RO-275 (3, 10 and 30 mg/kg, intraperitoneally injected) can save the reduction of working memory in rats. [1]
AliasRO275
Chemical Properties
Molecular Weight351.79
FormulaC18H14ClN5O
Cas No.2648837-04-9
SmilesO=C(N)C1=NC(C#CC=2C=CN=C(Cl)C2C)=C(N1C=3C=NC=CC3)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4 mg/mL (11.37 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8426 mL14.2130 mL28.4260 mL142.1302 mL
5 mM0.5685 mL2.8426 mL5.6852 mL28.4260 mL
10 mM0.2843 mL1.4213 mL2.8426 mL14.2130 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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