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Cilobradine hydrochloride
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
Catalog No. T10813Cas No. 186097-54-1
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Purity:97.46%
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Cilobradine hydrochloride
Catalog No. T10813Alias DK-AH 269Cas No. 186097-54-1
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $142 | In Stock | |
| 10 mg | $214 | In Stock | |
| 25 mg | $355 | In Stock | |
| 50 mg | $497 | In Stock | |
| 100 mg | $678 | In Stock |
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Bioactivity
Chemical Properties
| Description | Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels. |
| In vitro | Cilobradine hydrochloride is an HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine hydrochloride inhibits WT mHCN2 channel current by 86%. In contrast, I432A and A425G channel currents were only reduced by 14% and 19%, respectively, by this concentration of Cilobradine hydrochloride. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine hydrochloride (8 ± 2% inhibition)[1]. |
| Alias | DK-AH 269 |
| Molecular Weight | 519.07 |
| Formula | C28H39ClN2O5 |
| Cas No. | 186097-54-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 112.5 mg/mL (216.7 mM) H2O: 91 mg/mL (175.31 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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