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Rp-8-bromo-Cyclic AMPS (sodium salt)

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Catalog No. T36677Cas No. 925456-59-3

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.

Rp-8-bromo-Cyclic AMPS (sodium salt)

Rp-8-bromo-Cyclic AMPS (sodium salt)

😃Good
Catalog No. T36677Cas No. 925456-59-3
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.
Pack SizePriceAvailabilityQuantity
500 μg$43835 days
1 mg$65835 days
5 mg$2,40035 days
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Product Introduction

Bioactivity
Description
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.
Chemical Properties
Molecular Weight446.15
FormulaC10H10BrN5NaO5PS
Cas No.925456-59-3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 30 mg/mL
DMSO: 25 mg/mL
PBS (pH 7.2): 10 mg/mL
Ethanol: 0.5 mg/mL

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Keywords

Rp 8 bromo Cyclic AMPS (sodium salt)Rp-8-bromo-Cyclic AMPSRp8bromoCyclic AMPS (sodium salt)
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