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Rp-8-bromo-Cyclic AMPS (sodium salt)

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Catalog No. T36677Cas No. 925456-59-3

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.

Rp-8-bromo-Cyclic AMPS (sodium salt)

Rp-8-bromo-Cyclic AMPS (sodium salt)

😃Good
Catalog No. T36677Cas No. 925456-59-3
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.
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500 μgInquiry35 days
1 mgInquiry35 days
5 mgInquiry35 days
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Product Introduction

Bioactivity
Description
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.
Chemical Properties
Molecular Weight446.15
FormulaC10H10BrN5NaO5PS
Cas No.925456-59-3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 30 mg/mL (67.24 mM), Sonication is recommended.
DMSO: 25 mg/mL (56.03 mM), Sonication is recommended.
PBS (pH 7.2): 10 mg/mL (22.41 mM), Sonication is recommended.
Ethanol: 0.5 mg/mL (1.12 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
1 mM2.2414 mL11.2070 mL22.4140 mL112.0699 mL
PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
5 mM0.4483 mL2.2414 mL4.4828 mL22.4140 mL
10 mM0.2241 mL1.1207 mL2.2414 mL11.2070 mL
20 mM0.1121 mL0.5603 mL1.1207 mL5.6035 mL
DMSO/DMF
1mg5mg10mg50mg
50 mM0.0448 mL0.2241 mL0.4483 mL2.2414 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

Rp 8 bromo Cyclic AMPS (sodium salt)Rp-8-bromo-Cyclic AMPSRp8bromoCyclic AMPS (sodium salt)
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