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RR-11a

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RR-11a

Catalog No. T12769Cas No. 1361390-56-8

RR-11a is a synthetic enzyme legumain inhibitor. This compound specifically targets and inhibits the activity of legumain, an enzyme implicated in various biological processes. RR-11a's synthetic nature allows for precise modulation of legumain activity, making it a valuable tool in biochemical research and potential therapeutic applications.

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Pack Size	Price	Availability	Quantity
25 mg	$1,980	6-8 weeks

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Product Introduction

Bioactivity

Description	RR-11a is a synthetic enzyme legumain inhibitor. This compound specifically targets and inhibits the activity of legumain, an enzyme implicated in various biological processes. RR-11a's synthetic nature allows for precise modulation of legumain activity, making it a valuable tool in biochemical research and potential therapeutic applications.
Targets&IC50	Legumain:31-55 nM (IC50)
In vitro	Legumain-targeted nanoparticles coupled with RR-11a demonstrate substantial ligand-receptor affinity, thereby enabling enhanced penetration and uptake within solid tumors by tumor cells.
In vivo	Tumor-bearing mice treated with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, It completely inhibits tumor growth.

Chemical Properties

Molecular Weight	560.51
Formula	C24H28N6O10
Cas No.	1361390-56-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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