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S65487 hydrochloride

Catalog No. T39135   CAS 1644543-95-2
Synonyms: S65487 hydrochloride, VOB560 hydrochloride

S65487 (VOB560) hydrochloride is a potent and selective Bcl-2 inhibitor. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities.

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S65487 hydrochloride Chemical Structure
S65487 hydrochloride, CAS 1644543-95-2
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Biological Description
Chemical Properties
Storage & Solubility Information
Description S65487 (VOB560) hydrochloride is a potent and selective Bcl-2 inhibitor. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities.
In vitro S65487 hydrochloride binds to the BH3 hydrophobic groove of BCL-2. S65487 hydrochloride induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC 50 s in the low nM range[1].
In vivo S65487 hydrochloride induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 hydrochloride in combination with the MCL-1-specific inhibitor, S64315/MIK665[1].
Synonyms S65487 hydrochloride, VOB560 hydrochloride
Molecular Weight 753.73
Formula C41H42Cl2N6O4
CAS No. 1644543-95-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Arnaud Le Tiran, et al. Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax. Cancer Research. July 2021.

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Keywords

S65487 hydrochloride 1644543-95-2 S 65487 Hydrochloride S-65487 Hydrochloride S-65487 hydrochloride VOB 560 Hydrochloride VOB560 hydrochloride VOB560 Hydrochloride VOB-560 Hydrochloride S65487 Hydrochloride inhibitor inhibit

 

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