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S65487 sulfate

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Catalog No. T40070Cas No. 2416937-01-2
Alias VOB560 sulfate

S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.

S65487 sulfate

S65487 sulfate

😃Good
Catalog No. T40070Alias VOB560 sulfateCas No. 2416937-01-2
S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.
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Product Introduction

Bioactivity
Description
S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.
In vitro
S65487 effectively targets the BH3 hydrophobic groove of BCL-2, leading to the induction of apoptosis across various hematological cancer cell lines. Additionally, it significantly inhibits cell proliferation, demonstrating potency with IC50 values within the low nanomolar range[1].
In vivo
S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression is observed in xenograft models of lymphoid malignancies in mouse and rat at well-tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor S64315/MIK665[1].
AliasVOB560 sulfate
Chemical Properties
Molecular Weight815.34
FormulaC41H43ClN6O8S
Cas No.2416937-01-2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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