S65487 sulfate

S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.

Catalog No. T40070Cas No. 2416937-01-2

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S65487 sulfate

Catalog No. T40070Cas No. 2416937-01-2

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10 mg	$581	Backorder

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Product Introduction

Bioactivity

Description	S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.
In vitro	S65487 effectively targets the BH3 hydrophobic groove of BCL-2, leading to the induction of apoptosis across various hematological cancer cell lines. Additionally, it significantly inhibits cell proliferation, demonstrating potency with IC50 values within the low nanomolar range[1].
In vivo	S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression is observed in xenograft models of lymphoid malignancies in mouse and rat at well-tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor S64315/MIK665[1].
Alias	VOB560 sulfate

Chemical Properties

Molecular Weight	815.34
Formula	C₄₁H₄₃ClN₆O₈S
Cas No.	2416937-01-2

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

VOB-560 SulfateS65487 sulfateVOB 560 SulfateVOB560 SulfateS-65487 sulfateS-65487 SulfateS65487 SulfateS 65487 Sulfate