Shopping Cart
- Remove All
- Your shopping cart is currently empty
S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | 551 € | Backorder |
Description | S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y, while showing poor affinity for MCL-1, BFL-1, and BCL-XL. It induces apoptosis and possesses anticancer activities. |
In vitro | S65487 effectively targets the BH3 hydrophobic groove of BCL-2, leading to the induction of apoptosis across various hematological cancer cell lines. Additionally, it significantly inhibits cell proliferation, demonstrating potency with IC50 values within the low nanomolar range[1]. |
In vivo | S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression is observed in xenograft models of lymphoid malignancies in mouse and rat at well-tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor S64315/MIK665[1]. |
Alias | VOB560 sulfate |
Molecular Weight | 815.34 |
Formula | C41H43ClN6O8S |
Cas No. | 2416937-01-2 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.