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SCO-267
🥰Excellent
Catalog No. T39140Cas No. 1656261-09-4
SCO-267 is a potent allosteric full agonist of the GPR40 receptor, making it a valuable tool in studying chronic diseases like diabetes.
SCO-267
🥰Excellent
Catalog No. T39140Cas No. 1656261-09-4
SCO-267 is a potent allosteric full agonist of the GPR40 receptor, making it a valuable tool in studying chronic diseases like diabetes.
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Product Introduction
Bioactivity
Chemical Properties
| Description | SCO-267 is a potent allosteric full agonist of the GPR40 receptor, making it a valuable tool in studying chronic diseases like diabetes. |
| In vitro | SCO-267, when applied to CHO cells, stimulates the Gαq, Gαs, and Gα12/13 pathways alongside β-Arrestin recruitment. It functions as an allosteric partner to fasiglifam and interacts with an endogenous ligand[1]. |
| In vivo | SCO-267, administered orally at doses of 1 or 10 mg/kg, enhances insulin sensitivity and demonstrates a prolonged effect in reducing glucose levels. This was observed in a study using N-STZ rat models, confirming the compound's efficacy in modulating glucose metabolism at specified dosages. |
| Molecular Weight | 614.787 |
| Formula | C36H46N4O5 |
| Cas No. | 1656261-09-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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