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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
1 mL x 10 mM (in DMSO) | Inquiry | Backorder |
Description | Scutebarbatine W can inhibit nitric oxide production efficiently with IC50 values of lower than 50 μM, it may have potential effects on the reduction of neuroinflammation. |
In vitro | The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as Scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7) and Scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. |
Molecular Weight | 575.65 |
Formula | C33H37NO8 |
Cas No. | 1312716-25-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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