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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $293 | 35 days | |
5 mg | $460 | 35 days | |
10 mg | $838 | 35 days |
Description | SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH). 1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020) |
Molecular Weight | 313.19 |
Formula | C11H6F3N5O3 |
Cas No. | 2379550-82-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Ethanol: 30 mg/mL DMSO: 25 mg/mL DMF: 10 mg/mL |
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