SID 7969543 is a selective SF-1 inhibitor with potential anticancer activity, inhibits SF-1-triggered luciferase expression and can be used for cancer research.

SFRE:30 nM, SF1:760 nM

SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. In a functional activity assay, SID 7969543 was used to evaluate the response of HEK 293T cells co-transfected with a plasmid encoding full-length SF-1 and a vector expressing the fluorokinase gene under the control of five tandem natural SF-1 response elements (SFRE). SID 7969543 has an IC50 of 30 nM and significantly inhibits SF-1-induced fluorokinase expression. [1]