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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $670 | Backorder | |
1 mL x 10 mM (in DMSO) | $1,020 | Backorder |
Description | Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer. |
In vitro | We analyzed the antitumor efficacy of sikokianin C against human colon cancer cells in vitro and in vivo. Sikokianin C greatly suppressed the proliferation of HT29 colon cancer cells with an IC50 value of 1.6 μM, and CBS is the target of sikokianin C in mammalian cells, as evidenced by CBS knockdown analyses. Moreover, sikokianin C induced the apoptosis of HT29 cancer cells in a dose-dependent manner. Treating mice with sikokianin C dramatically reduced the tumor volume and the weight of the colon cancer xenograft in vivo. These results indicate that the selective CBS inhibitor sikokianin C can potentially be used for the treatment of colon cancer.[1] |
Molecular Weight | 556.52 |
Formula | C31H24O10 |
Cas No. | 159813-69-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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