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Sikokianin C

Name: Sikokianin C
Brand: TargetMol
SKU: TN5021
Price: 59 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. TN5021Cas No. 159813-69-1

Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer.

Sikokianin C

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Catalog No. TN5021Cas No. 159813-69-1

Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer.

Pack Size	Price	Availability	Quantity
5 mg	$670	Backorder
1 mL x 10 mM (in DMSO)	$1,020	Backorder

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Product Introduction

Bioactivity

Description

Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer.

In vitro

We analyzed the antitumor efficacy of sikokianin C against human colon cancer cells in vitro and in vivo. Sikokianin C greatly suppressed the proliferation of HT29 colon cancer cells with an IC50 value of 1.6 μM, and CBS is the target of sikokianin C in mammalian cells, as evidenced by CBS knockdown analyses. Moreover, sikokianin C induced the apoptosis of HT29 cancer cells in a dose-dependent manner. Treating mice with sikokianin C dramatically reduced the tumor volume and the weight of the colon cancer xenograft in vivo. These results indicate that the selective CBS inhibitor sikokianin C can potentially be used for the treatment of colon cancer.[1]

Chemical Properties

Molecular Weight	556.52
Formula	C₃₁H₂₄O₁₀
Cas No.	159813-69-1
Smiles	O=C1[C@@]([C@H](OC=2C1=C(O)C=C(O)C2)C3=CC=C(OC)C=C3)([C@]4([C@@H](OC=5C(C4=O)=C(O)C=C(O)C5)C6=CC=C(O)C=C6)[H])[H]
Relative Density.	1.521 g/cm3 (Predicted)

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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Keywords

Sikokianin C