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SK1-IN-1
🥰Excellent
Catalog No. T12927Cas No. 1218816-71-7
SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.
SK1-IN-1
🥰Excellent
Purity: 98.72%
Catalog No. T12927Cas No. 1218816-71-7
SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $216 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $305 | In Stock |
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Purity:98.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases. |
| Targets&IC50 | SPHK1:58 nM |
| In vitro | SK1-IN-1 can inhibit sphingosine kinase 1 (SPHK1) with an IC50 value of 58 nM. |
| In vivo | b>METHODS: SK1-IN-1 (1 mg/kg, intravenous injection; 3 mg/kg, oral administration) was studied for its pharmacokinetic properties in rats. RESULTS: SK1-IN-1 showed moderate oral bioavailability and acceptable blood circulation half-life. The bioavailability of SK1-IN-1 in rats after oral administration was 17.6%, and the half-lives in rat blood circulation after intravenous injection and oral administration were 4.30 hours and 7.5 hours, respectively. [1] |
| Molecular Weight | 398.5 |
| Formula | C22H30N4O3 |
| Cas No. | 1218816-71-7 |
| Smiles | C(CC1CCCC1)C2=NC(=NO2)C3=CC=C([C@@H](NC(=O)[C@@H]4[C@@H](O)CCN4)C)C=C3 |
| Relative Density. | 1.200 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (200.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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