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W140 HBr

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Purity:99.34%

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COA HNMR HPLC

W140 HBr

Catalog No. T60204Cas No. 1246817-25-3

[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM.

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Pack Size	Price	Availability
1 mg	$117	In Stock
2 mg	$175	In Stock
5 mg	$268	In Stock
10 mg	$395	In Stock
25 mg	$592	In Stock
50 mg	$828	In Stock
100 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock

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Product Introduction

Bioactivity

Description	[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM.
In vitro	In a GTP-gSbindingassay, activation of hS1P1 receptors by physiological agonist S1P alone or in the presence of 10 μM [(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide, the EC50 value was 0.8 nM or 50nM, respectively.

Chemical Properties

Molecular Weight	423.28
Formula	C16H28BrN2O4P
Cas No.	1246817-25-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (129.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3625 mL	11.8125 mL	23.6250 mL	118.1251 mL
5 mM	0.4725 mL	2.3625 mL	4.7250 mL	23.6250 mL
10 mM	0.2363 mL	1.1813 mL	2.3625 mL	11.8125 mL
20 mM	0.1181 mL	0.5906 mL	1.1813 mL	5.9063 mL
50 mM	0.0473 mL	0.2363 mL	0.4725 mL	2.3625 mL
100 mM	0.0236 mL	0.1181 mL	0.2363 mL	1.1813 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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