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SKF 100398
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Catalog No. T40884Cas No. 77453-01-1
Alias d(CH2)5Tyr(Et)VAVP
SKF 100398, also known as d(CH2)5Tyr(Et)VAVP, is a particular analog of arginine vasopressin (AVP). It acts as a specific antagonist, specifically targeting the antidiuretic effect caused by both exogenous and endogenous AVP.
SKF 100398
😃Good
Catalog No. T40884Alias d(CH2)5Tyr(Et)VAVPCas No. 77453-01-1
SKF 100398, also known as d(CH2)5Tyr(Et)VAVP, is a particular analog of arginine vasopressin (AVP). It acts as a specific antagonist, specifically targeting the antidiuretic effect caused by both exogenous and endogenous AVP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SKF 100398, also known as d(CH2)5Tyr(Et)VAVP, is a particular analog of arginine vasopressin (AVP). It acts as a specific antagonist, specifically targeting the antidiuretic effect caused by both exogenous and endogenous AVP. |
| In vivo | SKF 100398 specifically counteracts the water-retention effect of both externally supplied and internally generated arginine vasopressin (AVP)[1]. At a dosage of 8 μg/kg administered intravenously, SKF 100398 effectively nullifies AVP’s antidiuretic action[1]. The study was conducted on male Sprague-Dawley rats weighing 250-300 g[1], demonstrating that this compound, when given intravenously at 8 μg/kg, completely inhibits the antidiuretic impact of externally administered AVP (4 ng/kg body wt i.v.). |
| Alias | d(CH2)5Tyr(Et)VAVP |
| Molecular Weight | 1136.4 |
| Formula | C53H77N13O11S2 |
| Cas No. | 77453-01-1 |
| Relative Density. | 1.44g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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