Shopping Cart
- Remove All
Your shopping cart is currently empty
SLM6031434 HCl
😃Good
Catalog No. T28806Cas No. 1897379-34-8
Alias SLM-6031434 HCl, SLM 6031434 HCl
SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis.
SLM6031434 HCl
😃Good
Catalog No. T28806Alias SLM-6031434 HCl, SLM 6031434 HClCas No. 1897379-34-8
SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 121 € | 35 days | |
| 5 mg | 397 € | 35 days | |
| 10 mg | 546 € | 35 days |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "SLM6031434 HCl"
Fingolimod hydrochloride
FTY720 HCl, Fingolimod (FTY720) HCl
T2539162359-56-0
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
- 33 €
Size
QTY
MP-A08
T16128219832-49-2
MP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively].
- 31 €
Size
QTY
Siponimod
Cited
BAF-312
T64031230487-00-9
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibits >1000-fold over S1P2, S1P3 and S1P4 receptors.
- 31 €
Size
QTY
CitedOzanimod
RPC-1063
T69231306760-87-1
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclerosis.
- 38 €
Size
QTY
Fingolimod Cited
FTY-720A, FTY-720
T7939162359-55-9
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
- 47 €
Size
QTY
CitedASP-4058
T10385952565-91-2In house
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice.
- 95 €
Size
QTY
LX-2931
LX-3305, LX3305, LX2931, LX 3305, LX 2931, ACB20034
T27864948840-25-3In house
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.
- 245 €
Size
QTY
CYM50374
T271061314212-81-1In house
CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.
- 332 €
Size
QTY
SLP9101555
T63047In house
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extracellular S1P sphingosine 1-phosphate (S1P) levels.
- 332 €
Size
QTY
SKI-178
T90141259484-97-3
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
- 38 €
Size
QTY
Ceranib-2
3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one
T107611402830-75-4In house
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.
- 44 €
Size
QTY
K145 hydrochloride Cited
TQ01381449240-68-9In house
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
- 47 €
Size
QTY
CitedSelect Batch
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis. |
| In vitro | b>METHODS: U937 cells exposed to 1 μM FTY720 were treated with concentrations of SLM6031434 HCl (0.1, 0.3 μM, 2 hours), harvested by centrifugation and processed for LC/MS. RESULTS: SLM6031434 HCl blocked FTY720 phosphorylation in cultured U937 cells. [1] |
| In vivo | b>METHODS: SLM6031434 HCl (10 mg/kg, intraperitoneal injection) was administered to mice lacking a functional SphK1 allele (Sphk1−/−) /SphK2 deficient (Sphk2−/−) and whole blood was processed for LC/MS analysis. RESULTS: Administration of SLM6031434 HCl to mice lacking a functional SphK1 allele (Sphk1−/−) resulted in a decrease in blood S1P; SLM6031434 HCl did not affect blood S1P concentrations in SphK2 deficient (Sphk2−/−) mice. [1] |
| Alias | SLM-6031434 HCl, SLM 6031434 HCl |
| Molecular Weight | 489.96 |
| Formula | C22H31ClF3N5O2 |
| Cas No. | 1897379-34-8 |
| Smiles | C(=N)(N)N1[C@@H](CCC1)C2=NC(=NO2)C3=CC(C(F)(F)F)=C(OCCCCCCCC)C=C3.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 30 mg/mL (61.23 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy SLM6031434 HCl | purchase SLM6031434 HCl | SLM6031434 HCl cost | order SLM6031434 HCl | SLM6031434 HCl chemical structure | SLM6031434 HCl in vivo | SLM6031434 HCl in vitro | SLM6031434 HCl formula | SLM6031434 HCl molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.