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SLM6031434 HCl
Catalog No. T28806Cas No. 1897379-34-8
Alias SLM-6031434 HCl, SLM 6031434 HCl
SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis.
SLM6031434 HCl
Catalog No. T28806Alias SLM-6031434 HCl, SLM 6031434 HClCas No. 1897379-34-8
SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $128 | 35 days | |
| 5 mg | $418 | 35 days | |
| 10 mg | $575 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SLM6031434 HCl is a SphK2 inhibitor with anti-fibrotic effects that reduces LPS-induced TNFα and IL-1β production and can be used to study renal fibrosis. |
| In vitro | b>METHODS: U937 cells exposed to 1 μM FTY720 were treated with concentrations of SLM6031434 HCl (0.1, 0.3 μM, 2 hours), harvested by centrifugation and processed for LC/MS. RESULTS: SLM6031434 HCl blocked FTY720 phosphorylation in cultured U937 cells. [1] |
| In vivo | b>METHODS: SLM6031434 HCl (10 mg/kg, intraperitoneal injection) was administered to mice lacking a functional SphK1 allele (Sphk1−/−) /SphK2 deficient (Sphk2−/−) and whole blood was processed for LC/MS analysis. RESULTS: Administration of SLM6031434 HCl to mice lacking a functional SphK1 allele (Sphk1−/−) resulted in a decrease in blood S1P; SLM6031434 HCl did not affect blood S1P concentrations in SphK2 deficient (Sphk2−/−) mice. [1] |
| Alias | SLM-6031434 HCl, SLM 6031434 HCl |
| Molecular Weight | 489.96 |
| Formula | C22H31ClF3N5O2 |
| Cas No. | 1897379-34-8 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 30 mg/mL (61.23 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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