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SKI-178

Catalog No. T9014Cas No. 1259484-97-3

SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.

SKI-178

SKI-178

Purity: 99.2%
Catalog No. T9014Cas No. 1259484-97-3
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Pack SizePriceAvailabilityQuantity
2 mg$41In Stock
5 mg$66In Stock
10 mg$116In Stock
25 mg$226In Stock
50 mg$363In Stock
100 mg$547In Stock
500 mg$1,170In Stock
1 mL x 10 mM (in DMSO)$73In Stock
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Purity:99.2%
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Product Introduction

Bioactivity
Description
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Targets&IC50
SPHK1:0.1-1.8 μM
In vitro
SKI-178 is a multi-targeted agent that functions both as an inhibitor of the SphKs as well as a disruptor of the microtubule network.?SKI-178 induced apoptosis arises from a synergistic interaction of these two activities.?SKI-178 is safe and effective in mouse models of AML, supporting its further development as a multi-targeted anti-cancer therapeutic agent[1].
Chemical Properties
Molecular Weight394.42
FormulaC21H22N4O4
Cas No.1259484-97-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (126.77 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5354 mL12.6768 mL25.3537 mL126.7684 mL
5 mM0.5071 mL2.5354 mL5.0707 mL25.3537 mL
10 mM0.2535 mL1.2677 mL2.5354 mL12.6768 mL
20 mM0.1268 mL0.6338 mL1.2677 mL6.3384 mL
50 mM0.0507 mL0.2535 mL0.5071 mL2.5354 mL
100 mM0.0254 mL0.1268 mL0.2535 mL1.2677 mL

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