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Soyasaponin Ac

Name: Soyasaponin Ac
Brand: TargetMol
SKU: TN2229
Rating: 4.5 (1 reviews)

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Catalog No. TN2229Cas No. 133882-74-3

Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells.

Soyasaponin Ac

😃Good

Catalog No. TN2229Cas No. 133882-74-3

Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells.

Pack Size	Price	Availability	Quantity
5 mg	$400	Backorder
1 mL x 10 mM (in DMSO)	$910	Backorder

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Product Introduction

Bioactivity

Description

Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells.

In vitro

Cell viability assay was used to analyze the drug resistance of A2780/PTX cells treated with four different common soyasaponins respectively,in order to screen out the most effective soyasaponin. Then,the most effective soyasaponin was used to detect the expression of epithelial-mesenchymal transition (EMT)-related marker proteins, including N-cadherin and E-cadherin,with Western blot and confocal microscopy. Finally,transwell assay and wound healing assay were applied to observe effect of soyasaponin on regulating cancer cell migration. Compared with other soyasaponins,Soyasaponin Ac most effectively reversed the drug resistance of A2780/PTX cells. The expression of N-cadherin decreased while that of Ecadherin increased in A2780/PTX cells when treated with Soyasaponin Ac for 48 h. The results of transwell and wound healing assay suggested that Soyasaponin Ac also reduced the migration of A2780/PTX cells.

Chemical Properties

Molecular Weight	1421.52
Formula	C₆₇H₁₀₄O₃₂
Cas No.	133882-74-3
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

Soyasaponin Ac