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SPR inhibitor 3
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Catalog No. T16924Cas No. 1292285-54-1
Alias SPRi3
SPR inhibitor 3 is an effective sepiapterin reductase inhibitor. SPR inhibitor 3 decreases neuropathic and inflammatory pain through a reduction of BH4 levels. SPR inhibitor 3 shows a high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM).
SPR inhibitor 3
😃Good
Catalog No. T16924Alias SPRi3Cas No. 1292285-54-1
SPR inhibitor 3 is an effective sepiapterin reductase inhibitor. SPR inhibitor 3 decreases neuropathic and inflammatory pain through a reduction of BH4 levels. SPR inhibitor 3 shows a high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $67 | 5 days | |
| 5 mg | $116 | 7-10 days | |
| 10 mg | $175 | 7-10 days | |
| 1 mL x 10 mM (in DMSO) | $128 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SPR inhibitor 3 is an effective sepiapterin reductase inhibitor. SPR inhibitor 3 decreases neuropathic and inflammatory pain through a reduction of BH4 levels. SPR inhibitor 3 shows a high binding affinity to human SPR in a cell-free assay (IC50=74 nM) an |
| Targets&IC50 | Sepiapterin reductase:74 nM |
| In vitro | SPR inhibitor 3 obviously decreases SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 μM) without affecting the activity of the GTP cyclohydroxylase 1 enzyme [1]. |
| Alias | SPRi3 |
| Molecular Weight | 262.3 |
| Formula | C14H18N2O3 |
| Cas No. | 1292285-54-1 |
| Relative Density. | 1.241 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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