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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,820 | 8-10 weeks | |
50 mg | $2,380 | 8-10 weeks | |
100 mg | $3,100 | 8-10 weeks |
Description | ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively. |
In vitro | ST4206 inhibits agonist-induced cAMP accumulation (IC50: 990 nM)[1]. |
In vivo | ST4206, administered orally at doses of 10, 20, and 40 mg/kg, counteracts haloperidol-induced catalepsy and enhances motor activity in mice in a dose-dependent fashion. At dosages of 20 and 40 mg/kg, the compound markedly augments the number of contralateral turns in rats triggered by l-DOPA[1]. Demonstrating oral efficacy at concentrations of 10, 20, and 40 mg/kg, ST4206 effectively mitigates haloperidol-induced catalepsy in mice[2]. |
Molecular Weight | 286.29 |
Formula | C12H14N8O |
Cas No. | 1246018-36-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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