Shopping Cart

Remove All

Your shopping cart is currently empty

Taltobulin hydrochloride (228266-40-8 free base)

Catalog No. T13073L

Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
5 mg	$206	Backorder
10 mg	$320	Backorder
50 mg	$971	Backorder
100 mg	Inquiry	Backorder
200 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$230	Backorder

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
In vitro	The growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) inhibited by Taltobulin (HTI-286; 0.2-7.3 nM; 3 days)(with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM).
In vivo	In athymic nu/nu female mice, Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) . Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively.
Alias	SPA-110 hydrochloride, Taltobulin hydrochloride, HTI-286 hydrochloride

Chemical Properties

Molecular Weight	510.11
Formula	C27H44ClN3O4
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (196.04 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9604 mL	9.8018 mL	19.6036 mL	98.0181 mL
5 mM	0.3921 mL	1.9604 mL	3.9207 mL	19.6036 mL
10 mM	0.1960 mL	0.9802 mL	1.9604 mL	9.8018 mL
20 mM	0.0980 mL	0.4901 mL	0.9802 mL	4.9009 mL
50 mM	0.0392 mL	0.1960 mL	0.3921 mL	1.9604 mL
100 mM	0.0196 mL	0.0980 mL	0.1960 mL	0.9802 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc