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tCFA15

Name: tCFA15
Brand: TargetMol
SKU: T13917
Price: 34 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T13917Cas No. 220757-88-0

tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.

tCFA15

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Catalog No. T13917Cas No. 220757-88-0

tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.

Pack Size	Price	Availability
5 mg	$315	6-8 weeks
25 mg	$987	6-8 weeks
50 mg	$1,360	6-8 weeks
100 mg	$1,990	6-8 weeks
1 mL x 10 mM (in DMSO)	$318	6-8 weeks

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Product Introduction

Bioactivity

Description

tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.

In vitro

tCFA15 (10 nM-1μM) dose-dependently promotes the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and this effect is through Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures[1]. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis[2].

Chemical Properties

Molecular Weight	364.61
Formula	C₂₄H₄₄O₂
Cas No.	220757-88-0
Relative Density.	0.910 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 130 mg/mL (356.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7427 mL	13.7133 mL	27.4266 mL	137.1328 mL
5 mM	0.5485 mL	2.7427 mL	5.4853 mL	27.4266 mL
10 mM	0.2743 mL	1.3713 mL	2.7427 mL	13.7133 mL
20 mM	0.1371 mL	0.6857 mL	1.3713 mL	6.8566 mL
50 mM	0.0549 mL	0.2743 mL	0.5485 mL	2.7427 mL
100 mM	0.0274 mL	0.1371 mL	0.2743 mL	1.3713 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tCFA15tCFA-15