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Product Introduction

Bioactivity

Description

Tectoquinone exhibits strong mosquito larvicidal activity.

In vitro

Mosquito larvicidal activities of methanolic extracts from different plant parts of red heartwood-type Cryptomeria japonica D. Don against the fourth-instar larvae of Aedes aegypti and Aedes albopictus were examined. Results of mosquito larvicidal tests demonstrated that the n-hexane fraction of C. japonica sapwood methanolic extract had an excellent inhibitory effect against the larvae of A. aegypti and A. albopictus and its LC50 values were 2.4 and 3.3 microg/ml, respectively, in 24h. Following the bioactivity-guided fractionation procedure, the active constituent isolated from C. japonica sapwood was characterized as Tectoquinone by spectroscopic analyses. The LC50 values of Tectoquinone against A. aegypti and A. albopictus in 24h were 3.3 and 5.4 microg/ml, respectively. In addition, comparisons of mosquito larvicidal activity of anthraquinone congeners demonstrated that anthraquinone skeleton with a methyl group at C-2 position, such as Tectoquinone, exhibited the strongest mosquito larvicidal activity.

Chemical Properties

Molecular Weight	222.24
Formula	C₁₅H₁₀O₂
Cas No.	84-54-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 2.22 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4996 mL	22.4982 mL	44.9964 mL	224.9820 mL
5 mM	0.8999 mL	4.4996 mL	8.9993 mL	44.9964 mL
10 mM	0.4500 mL	2.2498 mL	4.4996 mL	22.4982 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

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Keywords

Tectoquinone