Temporin A, a short alpha-helical antimicrobial peptide derived from the skin of Rana temporaria, exhibits a wide-ranging efficacy against Gram-positive bacteria. It directly interacts with the cell membrane of microorganisms and remains non-toxic to erythrocytes at antimicrobial concentrations. Additionally, Temporin A demonstrates antifungal properties against yeast-like Candida albicans.

Temporin A (TA), a small, basic, highly hydrophobic antimicrobial peptide amide (FLPLIGRVLSGIL-NH2) derived from the skin of the European red frog, Rana temporaria, exhibits a broad spectrum of antibiotic activities. These activities are effective against a wide range of microorganisms, including both Methicillin-sensitive and -resistant Staphylococcus aureus, along with Vancomycin-resistant Enterococcus faecium strains[2].