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Thalidomide-NH-PEG3-COOH

Name: Thalidomide-NH-PEG3-COOH
Brand: TargetMol
SKU: T39925
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T39925Cas No. 2375283-62-6

Alias Thalidomide-NH-PEG3-COOH

Thalidomide-NH-PEG3-COOH, a conjugate of the E3 ligase ligand-linker synthesized compound, integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology.

Thalidomide-NH-PEG3-COOH

😃Good

Catalog No. T39925Alias Thalidomide-NH-PEG3-COOHCas No. 2375283-62-6

Thalidomide-NH-PEG3-COOH, a conjugate of the E3 ligase ligand-linker synthesized compound, integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology.

Pack Size	Price	Availability	Quantity
50 mg	Inquiry	Backorder
100 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	Thalidomide-NH-PEG3-COOH, a conjugate of the E3 ligase ligand-linker synthesized compound, integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology.
In vitro	PROTACs consist of two distinct ligands linked together; one targets an E3 ubiquitin ligase, and the other targets the protein of interest. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
Alias	Thalidomide-NH-PEG3-COOH

Chemical Properties

Molecular Weight	477.47
Formula	C₂₂H₂₇N₃O₉
Cas No.	2375283-62-6
Relative Density.	1.417 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Thalidomide NH PEG3 COOHThalidomideNHPEG3COOHThalidomide-NH-PEG-3-COOH