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Thalidomide-O-C10-NH2

Name: Thalidomide-O-C10-NH2
Brand: TargetMol
SKU: T39378
Price: 47 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T39378Cas No. 1957236-08-6

Alias Thalidomide-O-C10-NH2

Thalidomide-O-C10-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a cereblon ligand derived from Thalidomide with a linker crucial for PROTAC technology.

Thalidomide-O-C10-NH2

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Catalog No. T39378Alias Thalidomide-O-C10-NH2Cas No. 1957236-08-6

Thalidomide-O-C10-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a cereblon ligand derived from Thalidomide with a linker crucial for PROTAC technology.

Pack Size	Price	Availability	Quantity
25 mg	$1,520	Backorder

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Product Introduction

Bioactivity

Description	Thalidomide-O-C10-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a cereblon ligand derived from Thalidomide with a linker crucial for PROTAC technology.
In vitro	PROTACs consist of two ligands, one targeting an E3 ubiquitin ligase and the other a specific protein, connected by a linker; they leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
Alias	Thalidomide-O-C10-NH2

Chemical Properties

Molecular Weight	429.517
Formula	C₂₃H₃₁N₃O₅
Cas No.	1957236-08-6
Relative Density.	1.234 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Keywords

Thalidomide-O-C-10-NH2Thalidomide O C10 NH2ThalidomideOC10NH2