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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $323 | Backorder | |
5 mg | $788 | Backorder | |
10 mg | $1,080 | Backorder | |
25 mg | $1,630 | Backorder |
Description | Tipelukast (KCA 757) is a novel orally available leukotriene receptor antagonist with anti-inflammatory activity that reduces fibrosis and down-regulates TIMP-1, type 1 collagen.Tipelukast is used in the study of asthma. |
In vitro | Tipelukast inhibits the binding of [3H] LTD4 to the LTD4 receptors on the pulmonary cell membrane of guinea-pigs (IC50 = 2.3 μmol)[1]. |
In vivo | Fifteen minutes after an aerosolized antigen challenge, and inhaled 5 minutes later into the guinea pigs, Tipelukast significantly modifies the bronchoconstriction induced by UNDW[1]. Intravenous administration of Tipelukast (1 and 5 mg/kg) 15 minutes after antigen challenge dose-dependently reduces propranolol-induced bronchoconstriction (PIB) in guinea-pigs[1]. |
Alias | MN 001, KCA 757 |
Molecular Weight | 530.67 |
Formula | C29H38O7S |
Cas No. | 125961-82-2 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Ethanol: < 1 mg/mL |
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