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Tirzepatide monosodium salt

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Purity:99.69%

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COA HPLC MS

Tirzepatide monosodium salt

Catalog No. TP1111L1

Tirzepatide sodium salt (LY3298176 sodium salt) is a GIP and GLP-1 receptor agonist with neuroprotective activity and can be used to treat obesity.

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Pack Size	Price	Availability
1 mg	$263	In Stock
5 mg	$689	In Stock
10 mg	$1,130	In Stock
25 mg	$1,690	In Stock
50 mg	$2,320	In Stock
100 mg	$3,130	In Stock

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Product Introduction

Bioactivity

Description	Tirzepatide sodium salt (LY3298176 sodium salt) is a GIP and GLP-1 receptor agonist with neuroprotective activity and can be used to treat obesity.
In vitro	Under high glucose-induced conditions, treatment of SHSY5Y cells with Tirzepatide sodium salt at concentrations ranging from 0 to 0.4 μM for 7 days resulted in significant upregulation of CREB and BDNF mRNA expression. Additionally, it increased the protein levels of pAkt, MAP2, GAP43, AGBL4, GLUT4, SORBS1, and Bcl-2 while decreasing the protein level of BAX[1].
In vivo	In diet-induced obese (DIO) mice, Tirzepatide sodium salt (10 nM/kg, subcutaneous injection) reduced body weight and food consumption. It decreased glucose, insulin, leptin, and C-peptide levels[2].
Alias	LY-3298176 sodium salt, Tirzepatide sodium salt（2023788-19-2 free base）

Chemical Properties

Molecular Weight	4835.51
Formula	C225H347N48O68Na
Cas No.

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tirzepatide monosodium salt

Tirzepatide monosodium salt

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