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TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $329 | In Stock | |
5 mg | $826 | In Stock | |
10 mg | $1,090 | In Stock | |
25 mg | $1,650 | In Stock | |
50 mg | $2,230 | In Stock |
Description | TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1. |
Targets&IC50 | ALK:0.54 nM |
In vitro | TL13-22 prompted the concentrations of Aurora A, FER, PTK2 and RPS6KA1 kinase reduction at 11.3, 5.74, 18.4 and 65.9 nM, respectively. [1] |
Alias | TL 13-22 |
Molecular Weight | 947.5 |
Formula | C45H55ClN10O9S |
Cas No. | 2229036-65-9 |
Smiles | O=C1C=2C=CC=C(NCC(=O)NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C(Cl)C(=N5)NC=6C=CC=CC6S(=O)(=O)C(C)C)C(OC)=C4)CC3)C2C(=O)N1C7C(=O)NCCC7 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (211.08 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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