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TL13-22

🥰Excellent
Catalog No. T37084Cas No. 2229036-65-9
Alias TL 13-22

TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1.

TL13-22

TL13-22

🥰Excellent
Catalog No. T37084Alias TL 13-22Cas No. 2229036-65-9
TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1.
Pack SizePriceAvailabilityQuantity
1 mg$329 In Stock
5 mg$826 In Stock
10 mg$1,090 In Stock
25 mg$1,650 In Stock
50 mg$2,230 In Stock
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Product Introduction

Bioactivity
Description
TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC₅₀ value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1.
Targets&IC50
ALK:0.54 nM
In vitro
TL13-22 prompted the concentrations of Aurora A, FER, PTK2 and RPS6KA1 kinase reduction at 11.3, 5.74, 18.4 and 65.9 nM, respectively. [1]
AliasTL 13-22
Chemical Properties
Molecular Weight947.5
FormulaC45H55ClN10O9S
Cas No.2229036-65-9
SmilesO=C1C=2C=CC=C(NCC(=O)NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C(Cl)C(=N5)NC=6C=CC=CC6S(=O)(=O)C(C)C)C(OC)=C4)CC3)C2C(=O)N1C7C(=O)NCCC7
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (211.08 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0554 mL5.2770 mL10.5541 mL52.7704 mL
5 mM0.2111 mL1.0554 mL2.1108 mL10.5541 mL
10 mM0.1055 mL0.5277 mL1.0554 mL5.2770 mL
20 mM0.0528 mL0.2639 mL0.5277 mL2.6385 mL
50 mM0.0211 mL0.1055 mL0.2111 mL1.0554 mL
100 mM0.0106 mL0.0528 mL0.1055 mL0.5277 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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