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Tos-PEG2-NH-Boc

Name: Tos-PEG2-NH-Boc
Brand: TargetMol
SKU: T18850
Rating: 4.5 (1 reviews)

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Catalog No. T18850Cas No. 192132-77-7

Tos-PEG2-NH-Boc is a PEG-based linker for PROTACs that joins two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Tos-PEG2-NH-Boc

😃Good

Catalog No. T18850Cas No. 192132-77-7

Tos-PEG2-NH-Boc is a PEG-based linker for PROTACs that joins two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Pack Size	Price	Availability	Quantity
100 mg	Inquiry	7-10 days
500 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	Tos-PEG2-NH-Boc is a PEG-based linker for PROTACs that joins two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.
In vitro	PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase and the other to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade specific target proteins[1].

Chemical Properties

Molecular Weight	359.44
Formula	C₁₆H₂₅NO₆S
Cas No.	192132-77-7
Relative Density.	1.179 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (695.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7821 mL	13.9105 mL	27.8211 mL	139.1053 mL
5 mM	0.5564 mL	2.7821 mL	5.5642 mL	27.8211 mL
10 mM	0.2782 mL	1.3911 mL	2.7821 mL	13.9105 mL
20 mM	0.1391 mL	0.6955 mL	1.3911 mL	6.9553 mL
50 mM	0.0556 mL	0.2782 mL	0.5564 mL	2.7821 mL
100 mM	0.0278 mL	0.1391 mL	0.2782 mL	1.3911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tos-PEG2-NH-BocTos-PEG-2-NH-BocTosPEG2NHBocTos PEG2 NH BocPEGsAlkyl/ether