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tri-GalNAc-COOH

Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.

Catalog No. T39370Cas No. 1953146-81-0

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Purity:99.13%

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COA HNMR HPLC

tri-GalNAc-COOH

Catalog No. T39370Cas No. 1953146-81-0

Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$255	In Stock
5 mg	$639	In Stock
10 mg	$891	In Stock
25 mg	$1,370	In Stock
50 mg	$1,830	In Stock
100 mg	$2,490	In Stock
500 mg	$4,980	In Stock
1 mL x 10 mM (in DMSO)	$1,220	In Stock

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Product Introduction

Bioactivity

Description	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
In vitro	Tri-GalNAc-COOH, a biotin-free ASGPR ligand, cannot effectively transport NA-650 to HepG2, Huh7, or A549 cells [1].

Chemical Properties

Molecular Weight	1735.91
Formula	C₇₅H₁₃₄N₁₀O₃₅
Cas No.	1953146-81-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 225 mg/mL (129.6 mM), Sonication is recommended.

H2O: 20 mg/mL (11.52 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5761 mL	2.8803 mL	5.7607 mL	28.8033 mL
5 mM	0.1152 mL	0.5761 mL	1.1521 mL	5.7607 mL
10 mM	0.0576 mL	0.2880 mL	0.5761 mL	2.8803 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0288 mL	0.1440 mL	0.2880 mL	1.4402 mL
50 mM	0.0115 mL	0.0576 mL	0.1152 mL	0.5761 mL
100 mM	0.0058 mL	0.0288 mL	0.0576 mL	0.2880 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc