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TRV056
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TRV056
Catalog No. T40920Cas No. 812644-79-4
TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | Inquiry | Backorder | |
| 100 mg | Inquiry | Backorder |
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| Description | TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists. |
| In vitro | TRV056 is a "gain-of-function" ligand exhibiting over tenfold stronger allosteric coupling to Gq compared to Angiotensin II (AngII), thereby more effectively stimulating Gq-mediated cellular signaling, such as IP1 generation. As a Gq-biased AT1R agonist, it surpasses the endogenous ligand AngII in both efficacy of stimulating Gq-mediated signaling and in enhancing Gq coupling[1]. |
| Alias | TRV056 |
| Molecular Weight | 1103.249 |
| Formula | C52H74N14O13 |
| Cas No. | 812644-79-4 |
| Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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