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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Tubulin polymerization-IN-45, a tubulin-targeting agent, inhibits tubulin polymerization by binding to tubulin's colchicine site, inducing apoptotic cell death in hepatocellular cancer (HCC) cells [1]. |
In vitro | Tubulin polymerization-IN-45 (compound 18) demonstrates effective activity against hepatocellular carcinoma (HCC) cell lines, with IC50 values ranging from 0.6 to 2.9 μM. It also exhibits moderate inhibitory activity on microtubule polymerization (IC50 = 19 μM). Furthermore, Tubulin polymerization-IN-45 causes cell cycle arrest at the G2/M phase in Huh7 and Mahlavu cells and induces apoptosis in HCC cells [1]. |
Molecular Weight | 362.38 |
Formula | C20H18N4O3 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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