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TUG-770

😃Good
Catalog No. TQ0241Cas No. 1402601-82-4
Alias TUG770, TUG 770

TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.

TUG-770

TUG-770

😃Good
Purity: 97.6%
Catalog No. TQ0241Alias TUG770, TUG 770Cas No. 1402601-82-4
TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.
Pack SizePriceAvailabilityQuantity
1 mg55 €5 days
5 mg132 €5 days
10 mg210 €5 days
25 mg407 €7-10 days
50 mg652 €7-10 days
100 mg937 €7-10 days
500 mg1.881 €7-10 days
1 mL x 10 mM (in DMSO)202 €5 days
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Purity:97.6%
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Product Introduction

Bioactivity
Description
TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease.
Targets&IC50
FFA1/GPR40 (human):6 nM (EC50)
In vitro
TUG-770 shows good stability towards human liver microsomes (HLM) and demonstrates good permeability in the Caco-2 cell assay[1].
In vivo
In C57BL/6 male mice (5-6 weeks of age) fed a 60% fat diet D12492, TUG-770 (20 mg/kg; oral administration; daily; for 28 days) significantly improved glucose tolerance[1].
AliasTUG770, TUG 770
Chemical Properties
Molecular Weight307.32
FormulaC19H14FNO2
Cas No.1402601-82-4
SmilesOC(=O)CCc1ccc(cc1F)C#Cc1ccccc1CC#N
Relative Density.1.28 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 100 mg/mL (325.39 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2539 mL16.2697 mL32.5394 mL162.6969 mL
5 mM0.6508 mL3.2539 mL6.5079 mL32.5394 mL
10 mM0.3254 mL1.6270 mL3.2539 mL16.2697 mL
20 mM0.1627 mL0.8135 mL1.6270 mL8.1348 mL
50 mM0.0651 mL0.3254 mL0.6508 mL3.2539 mL
100 mM0.0325 mL0.1627 mL0.3254 mL1.6270 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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