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Umibecestat HCl
😃Good
Catalog No. T69664Cas No. 2365306-62-1 2369750-66-1
Alias CNP520 HCl, CNP-250 HCl, CNP250 HCl, CNP 520 HCl, AMG520 HCl, AMG 520 HCl
Umibecestat HCl (CNP520 HCl) is a highly efficient β-secretase (BACE1/BACE2) inhibitor, lowering Aβ levels in mice and rats, used in Alzheimer's disease research.
Umibecestat HCl
😃Good
Purity: 99.92%
Catalog No. T69664Alias CNP520 HCl, CNP-250 HCl, CNP250 HCl, CNP 520 HCl, AMG520 HCl, AMG 520 HClCas No. 2365306-62-1 2369750-66-1
Umibecestat HCl (CNP520 HCl) is a highly efficient β-secretase (BACE1/BACE2) inhibitor, lowering Aβ levels in mice and rats, used in Alzheimer's disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $3,020 | 1-2 weeks | |
| 50 mg | $3,980 | 1-2 weeks | |
| 100 mg | $5,500 | 1-2 weeks |
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Purity:99.92%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Umibecestat HCl (CNP520 HCl) is a highly efficient β-secretase (BACE1/BACE2) inhibitor, lowering Aβ levels in mice and rats, used in Alzheimer's disease research. |
| In vitro | Umibecestat HCl is a potent BACE-1 inhibitor that is selective for BACE-1 over other human pepsin-like aspartic proteases.[1] |
| In vivo | Methods: Umibecestat HCl (1.5mg/kg-51.3mg/kg, gavage, 72 hours) was administered to male rats, and the distribution of Aβ40 in rat brain tissue was measured 4 hours later. Results: At the highest dose, Aβ40 in brain tissue was reduced by 89.3±4.5%, and the 50% reduction in rat brain Aβ40 (ED50) was 2.4±0.31 mg/kg. [1] |
| Alias | CNP520 HCl, CNP-250 HCl, CNP250 HCl, CNP 520 HCl, AMG520 HCl, AMG 520 HCl |
| Molecular Weight | 550.26 |
| Formula | C19H16Cl2F7N5O2 |
| Cas No. | 2365306-62-1 2369750-66-1 |
| Smiles | C[C@]1(C=2N=C(NC(=O)C3=C(Cl)C=C(C(F)(F)F)C=N3)C=CC2F)N=C(N)[C@@]([C@](F)(F)F)(C)OC1.Cl |
Storage & Solubility Information
| Storage | keep away from direct sunlight | store at 4°C | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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