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VPC-14449
🥰Excellent
Catalog No. T24944Cas No. 1621375-32-3
Alias VPC14449
VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.
VPC-14449
🥰Excellent
Purity: 99.56%
Catalog No. T24944Alias VPC14449Cas No. 1621375-32-3
VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $392 | In Stock | |
| 5 mg | $952 | In Stock | |
| 10 mg | $1,290 | In Stock | |
| 25 mg | $1,920 | In Stock | |
| 50 mg | $2,500 | In Stock |
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Purity:99.56%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VPC-14449 is a selective androgen receptor DNA-binding domain (AR-DBD) inhibitor, useful in prostate cancer research. |
| Targets&IC50 | AR-DBD:0.34 μM |
| In vitro | Methods: LNCaP, C4-2, MR49F, and 22Rv1 cells were treated with VPC-14449 (0.01-100 μM, 24 hours) to test its inhibitory effect on AR-V7 transcriptional activity in cells. Results: VPC-14449 inhibited AR transcriptional activity and cell viability in LNCaP, C4-2, MR49F, and 22Rv1 cells.[1] |
| In vivo | Methods: Castrated mice were given VPC-14449 (100 mg/kg, ip, for 4 weeks) twice daily and LNCaP xenograft tumor volume and serum PSA were assessed. Results: VPC-14449 reduced tumor volume and abolished PSA production in the LNCaP xenograft model.[1] |
| Alias | VPC14449 |
| Molecular Weight | 394.09 |
| Formula | C10H10Br2N4OS |
| Cas No. | 1621375-32-3 |
| Smiles | BrC=1N=C(Br)N(C1)C=2N=C(SC2)N3CCOCC3 |
| Relative Density. | 2.12 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (253.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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