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WL47 TFA

😃Good
Catalog No. T78373
Alias WL 47 TFA

WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.

WL47 TFA

WL47 TFA

😃Good
Purity: 99.80%
Catalog No. T78373Alias WL 47 TFA
WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.
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1 mg$149Backorder
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Purity:99.80%
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Product Introduction

Bioactivity
Description
WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.
Targets&IC50
caveolin-1 ligand:23 nM (Kd)
In vitro
WL47 TFA is a high-affinity caveolin-1 (CAV1) ligand (Kd=23 nM) that efficiently disrupts CAV1 oligomers. WL47 TFA exhibits higher selectivity for CAV1 compared to BSA, casein and HEWL. [1]
AliasWL 47 TFA
Chemical Properties
Molecular Weight1814.16
FormulaC76H119F3N22O18S4
Smiles[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CCSC)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)=O)=O)CO)=O)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCCN.O=C(O)C(F)(F)F
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 20.00 mg/mL (11.02 mM), Sonication is recommended
DMSO: 40.00 mg/mL (22.05 mM), Sonication is recommended
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM0.5512 mL2.7561 mL5.5122 mL27.5610 mL
5 mM0.1102 mL0.5512 mL1.1024 mL5.5122 mL
10 mM0.0551 mL0.2756 mL0.5512 mL2.7561 mL
DMSO
1mg5mg10mg50mg
20 mM0.0276 mL0.1378 mL0.2756 mL1.3780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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