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YAP-TEAD-IN-1 TFA

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Catalog No. TP2160LCas No. 1659305-79-9

YAP-TEAD-IN-1 TFA, a competitive inhibitor of the YAP–TEAD interaction (IC50: 25 nM), exhibits higher binding affinity to TEAD1 (Kd: 15 nM) compared to YAP (50-171) (Kd: 40 nM).

YAP-TEAD-IN-1 TFA

YAP-TEAD-IN-1 TFA

😃Good
Catalog No. TP2160LCas No. 1659305-79-9
YAP-TEAD-IN-1 TFA, a competitive inhibitor of the YAP–TEAD interaction (IC50: 25 nM), exhibits higher binding affinity to TEAD1 (Kd: 15 nM) compared to YAP (50-171) (Kd: 40 nM).
Pack SizePriceAvailabilityQuantity
1 mg$1507-10 days
5 mg$3447-10 days
10 mg$5717-10 days
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Product Introduction

Bioactivity
Description
YAP-TEAD-IN-1 TFA, a competitive inhibitor of the YAP–TEAD interaction (IC50: 25 nM), exhibits higher binding affinity to TEAD1 (Kd: 15 nM) compared to YAP (50-171) (Kd: 40 nM).
Targets&IC50
YAP-TEAD:25 nM
In vitro
In a GST pull-down assay, YAP-TEAD-IN-1 (2 μM) is against endogenous YAP binding to GST-TEAD (1209-426), the Kd of His-YAP1209-426 is determined to be 40 nM.
Chemical Properties
FormulaC93H144ClN23O21S2.xC2HF3O2
Cas No.1659305-79-9
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YAPTEADIN1 TFAYAP TEAD IN 1 TFAYAP-TEAD-IN-1 TFA
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