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YL-365
Catalog No. T80753
YL-365 is a highly potent and selective GPR34 antagonist that exhibits excellent activity in neuropathic pain models for the study of neurologic diseases.
YL-365
YL-365
Catalog No. T80753
YL-365 is a highly potent and selective GPR34 antagonist that exhibits excellent activity in neuropathic pain models for the study of neurologic diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $71 | In Stock | |
| 5 mg | $172 | In Stock | |
| 10 mg | $278 | In Stock | |
| 25 mg | $562 | In Stock | |
| 50 mg | $893 | In Stock | |
| 100 mg | $1,420 | In Stock | |
| 200 mg | $1,920 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | YL-365 is a highly potent and selective GPR34 antagonist that exhibits excellent activity in neuropathic pain models for the study of neurologic diseases. |
| In vivo | Acute toxicity experiments on C57BL/6J mice showed that no mice died after i.p. (intraperitoneally) (200 mg/kg) treatment with YL-365. In a repeated dose toxicity study, following 14 consecutive days i.p. administration of YL-365 twice per day at the dose of 100 mg/kg, mice did not show noticeable change in body weight or any damage in diverse organs. Considering that GPR34 is also expressed in hematological system, the blood cell counts and other blood parameters were examined, and YL-365 did not show any effects on these blood parameters. All these results indicated low toxicity of YL-365 to mice. [1] |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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