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YM-254890
Catalog No. T17273Cas No. 568580-02-9
Alias YM254890, YM 254890
YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling.
YM-254890
Catalog No. T17273Alias YM254890, YM 254890Cas No. 568580-02-9
YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,199 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling. |
| In vitro | METHODS: The effects of YM-254890 on P2Y1 and P2Y12 signaling pathways were examined using C6-15 cells stably expressing human P2Y1 or P2Y12 receptors. RESULTS: 2MeSADP stimulation of P2Y1-C6-15 cells resulted in increased intracellular calcium mobilization. In this assay, YM-254890 inhibited the increase in [Ca2+]i (IC50: 0.031 μM). However, 40 μM of YM-254890 did not affect the 2MeSADP-induced inhibition of forskolin-stimulated adenylate cyclase activity in P2Y12-C6-15 cells [1]. |
| Alias | YM254890, YM 254890 |
| Molecular Weight | 960.08 |
| Formula | C46H69N7O15 |
| Cas No. | 568580-02-9 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (31.25 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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