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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $1,199 | In Stock |
Description | YM-254890, a macrocyclohexapeptide isolated from Chromobacterium sp, is a selective and potent inhibitor of Gαq/11 protein, inhibits ADP-induced platelet aggregation and inhibits G protein signaling. |
In vitro | METHODS: The effects of YM-254890 on P2Y1 and P2Y12 signaling pathways were examined using C6-15 cells stably expressing human P2Y1 or P2Y12 receptors. RESULTS: 2MeSADP stimulation of P2Y1-C6-15 cells resulted in increased intracellular calcium mobilization. In this assay, YM-254890 inhibited the increase in [Ca2+]i (IC50: 0.031 μM). However, 40 μM of YM-254890 did not affect the 2MeSADP-induced inhibition of forskolin-stimulated adenylate cyclase activity in P2Y12-C6-15 cells [1]. |
Alias | YM254890, YM 254890 |
Molecular Weight | 960.08 |
Formula | C46H69N7O15 |
Cas No. | 568580-02-9 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (31.25 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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